Diallyl disulfide suppresses SRC/Ras/ERK signaling-mediated proliferation and metastasis in human breast cancer by up-regulating miR-34a.

Diallyl disulfide suppresses SRC/Ras/ERK signaling-mediated proliferation and metastasis in human breast cancer by up-regulating miR-34a.

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Diallyl disulfide (DADS) is one of the major volatile components of garlic oil.DADS has various biological properties, including anticancer, antiangiogenic, Omega 3 Vegetarian and antioxidant effects.However, the anticancer mechanisms of DADS in human breast cancer have not been elucidated, particularly in vivo.

In this study, we demonstrated that the expression of miR-34a was up-regulated in DADS-treated MDA-MB-231 cells.miR-34a not only inhibited breast cancer growth but also enhanced the antitumor effect of DADS, both in vitro and in vivo.Furthermore, Src was identified Bottle as a target of miR-34a, with miR-34a inhibiting SRC expression and consequently triggering the suppression of the SRC/Ras/ERK pathway.

These results suggest that DADS could be a promising anticancer agent for breast cancer.miR-34a may also demonstrate a potential gene therapy agent that could enhance the antitumor effects of DADS.